发明名称 |
USE OF ANTIBODY CONJUGATED DEOXYCYTIDINE KINASE FOR ADEPT |
摘要 |
The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with enhanced activity towards nucleoside analogs used in cancer chemotherapy, and delivering the enzymes to specific target cells in a patient. The invention also provides modified deoxycytidine kinase (dCK) mutants with such enhanced activity. Furthermore, the invention provides antibody-conjugated enzymes that can be specifically delivered to leukemic blast cells in vivo or ex vivo. |
申请公布号 |
WO2004078215(A3) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2004US06303 |
申请日期 |
2004.03.01 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;LAVIE, ARNON;KONRAD, MANFRED;RAVANDI, FARHAD |
发明人 |
KONRAD, MANFRED;RAVANDI, FARHAD |
分类号 |
A61K39/395;A61K47/48;C07K16/28;C12N9/00;C12N9/12 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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