Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof

摘要

This invention provides a heterocyclic compound having potent tyrosine kinase-inhibiting activity represented by the formula: wherein m is an integer of 1 to 3; n is an integer of 1 or 2; R<1 >is a halogen atom or an optionally halogenated C1-2 alkyl group; each of R<2 >and R<3 >is, same or different, a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R<4 >is a group represented by the formula: wherein p is an integer of 2 to 5; R<5 >is a C1-4 alkyl group substituted by alkoxycarbonyl group, carbamoyl group, carbamoyloxy group, alkylsulfonyl group, alkylsulfinyl group, sulfamoyl group, carbamoylamino group, alkylsulfonylamino group, acylamino group, and the like; or a salt thereof and a pharmaceutical composition comprising thereof.