| 摘要 |
Strategies are disclosed for generating dendritic cells that possess immune stimulatory activity despite immune suppressive factors elaborated by the tumor. An aspe ct of the invention includes blocking the arginase pathway in dendritic cells that are pulsed with tumor antigens. Alternatively, dendritic cells modified according to the invention are placed proximally near tumor tissues so as to naturally acquire tumor antige ns and stimulate T cell responses. An object of this invention is to allow stimulation of Th1 immunity in cancer-bearing mammals that generally are predisposed to Th2 or anergic responses.
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