| 摘要 |
A compound represented by the structural formula I or a pharmaceutically acceptable salt thereof, wherein; A1 is OR6, N(R6)(R7), S(O)eR13 or (C(R6)(R7))1-6N(R6)(R7) and A2 is H, or A1 and A2 together are O, C(R6)(R7) or NOR6, Q is R5-phenyl, T is R4-aryl, b is 0, 1 or 2, b1 is 1 or 2, X is O, NR6, N(R6)C(O), OC(O)NR6 or N(R6)C(O)O, R4 and R5 are independently 1-3 substituents independently selected from the group consisting of H, halogeno, OR6, OC(O)R6, OC(O)N(R6)(R7), N(R6)(R7), C1-6 alkyl, CF3, C2F5, COR6, CO2R6, CON(R6)(R7), S(O)eR13, CN, OCF3, NR6CO2R16, NR6COR7, NR8CON(R6)(R7), R15-phenyl, R15-benzyl, NO2, N(R6)S(O)2R13 or S(O)2N(R6)(R7) or adjacent R4 substituents or adjacent R5 substituents can form a OCH2O group and R4 can also be R15-heteroaryl, R6, R7, R8, R8a, and R13 are independently selected from the group consisting of H, C1-6 alkyl, C2-C6 hydroxyalkyl, C1-C6 alkoxy-C1-C6 alkyl, R15-phenyl, and R15-benzyl or R6 and R7, together with the nitrogen to which they are attached, form a ring of 5 to 6 members, wherein 0, 1 or 2 ring members are selected from the group consisting of O, S and N(R19), R9 and R9a are independently selected from the group consisting of R6 and OR6, provided that when R9 is OH, X is N(R6)C(O), R10 is independently selected from the group consisting of H and C1-6 alkyl, R15 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, halogeno, CF3, C2F5, COR10, CO2R10, C(O)N(R10)2, S(O)eR10, CN, N(R10)COR10, N(R10)CON(R10)2 and NO2, R16 is C1-6 alkyl, R15-phenyl or R15-benzyl, R19 is H, C1-C6 alkyl, C(O)N(R10)2, CO2R10, (C(R8)(R9))fCO2R10 or (C(R8)(R9))uC(O)N(R10)2, f is 1-6, u is 0-6, Z is formula II or formula III, g is 1, j is 1 or 0, h is 2, k is 2 or 3, J is two hydrogen atoms or O, L is H, C1-C6 alkyl, C1-C6 alkenyl, CH2 cycloalkyl, R15-benzyl, R15-heteroaryl, C(O)R6, (CH2)mOR6, (CH2)mN(R6)(R7), (CH2)mC(O)OR6 or (CH2)mC(O)N(R6)(R7), L1 is H, R28 is H, OH, phenyl or H2NC(O) and R29 is H or R4-phenyl. The abovementioned compounds are useful in the treatment of asthma, cough, bronchospasm, central nervous system diseases, inflammatory diseases and gastrointestinal disorders.
|
