Pyrido [2,3-d] pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation

摘要

The compounds of formula I and II may be used for treating cell proliferation disorders, such as cancer and restenosis. In particular, 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. In Formula I and II; W is NH, S, SO, or SO2, X is O, S or NH, R1and R2 include heteroaryl, optionally substituted phenyl, or optionally substituted alkyl or cycloalkyl, R3 includes hydrogen or alkyl, R8 and R9 include hydrogen, alkyl, alkoxy, halo or amino, and Z is carboxy.