COMPOUNDS AND PREPARAITONS HAVING ANTIVIRAL EFFECT

摘要

Antiviral preparations containing, as the active ingredient, phorbol derivatives which are represented by the following general formula 1: wherein R1 represents -(CH2aX(CH2)bCH3, -(CH2cX(CH2)dYCH3, -CO(CH2)eCH3 or -(CH2)fCH3; R2 represents -CO(CH2)nCH3; and R3, R4 and R5 represent each hydrogen or aliphatic or aromatic carboxylate (wherein X and Y are each O or S; and a to f and n stand for each a numerical value); and show a specific safety index S.I.=EC50/EC50 (i.e., a ratio of the concentration at which HIV-1-induced ctyopathogenic effect (CPE) in MT-4 cells is inhibited by 50% to the concentration at which the survival of MT-4 cells is lowered by 50% in a cell proliferation test) of 10 or more. These preparations are efficacious particularly against human immunodeficiency virus (HIV).