发明名称 |
INTERLEUKIN-9 ANTAGONIST MUTEINS AND THEIR PHARMACOLOGICAL METHODS OF USE |
摘要 |
This invention relates to IL-9 muteins that inhibit the activity of wild-type IL-9, multimers and Fc-fusion constructs of IL-9 proteins, and an efficient method to purify IL-9 proteins produced by eukaryotic cells. Related formulations, dosages and methods of administration thereof for therapeutic purposes are also provided. More particularly, these IL-9 muteins, compositions, and methods provide a treatment option for individuals afflicted with conditions where inhibiting IL-9 mediated immune responses would be beneficial, such as allergy, asthma, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), pulmonary and gastro-intestinal mucus hyperplasia, inflammation, immunological disorders, leukemia, and lymphoma. |
申请公布号 |
WO2004103295(A2) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2004US15168 |
申请日期 |
2004.05.14 |
申请人 |
BAYER PHARMACEUTICALS CORPORATION;BOISVERT, DAVID, C.;LONGPHRE, MALINDA;ZAREMBA, SYDNEY, MORGAN;SHANAFELT, ARMEN, B. |
发明人 |
BOISVERT, DAVID, C.;LONGPHRE, MALINDA;ZAREMBA, SYDNEY, MORGAN;SHANAFELT, ARMEN, B. |
分类号 |
A61K;A61K38/20;C07K14/54 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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