| 摘要 |
Described herein is a system for inferring one or a population of biochemical interaction networks, including topology and chemical reaction rates and parameters, from dynamical or statical experimental data, with or without spatial localization information, and a database of possible interactions. Accordingly, the systems and methods described herein may be employed to infer the biochemical interaction networks that exist in a cell. To this end, the systems and methods described herein generate a plurality of possible candidate networks and then apply to these networks a forward simulation process to infer a network. Inferred networks may be analyzed via data fitting and other fitting criteria, to determine the likelihood that the network is correct. In this way, new and more complete models of cellular dynamics may be created.
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