Piperdine derivatives and their use as modulators of chemokine (especially ccr3) activity

摘要

The invention provides a compound of formula (I): T is C(O) or S(O)2; W is CH2, (CH2)2, CH(CH3), CH(CH3)O or cyclopropyl; X is O, CH2, C(O), S, S(O), S(O)2 or NR<3>; m is 0 or 1; R<1 >is optionally substituted aryl or optionally substituted heterocyclyl; R<2 >is alkyl (optionally substituted by OH), cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.