发明名称 |
METHOD OF SCREENING INHIBITOR BY USING INDUCTION OF INTERLEUKIN 18 PRODUCTION BY KERATINOCYTE, METHOD OF INDUCING ATOPIC DERMATITIS-LIKE SYMPTOM AND UTILIZATION OF THE SAME |
摘要 |
It is intended to provide various methods appropriately usable in clarifying the onset mechanism of atopic dermatitis (AD) and symptoms similar thereto and a remedy therefor with the use of the phenomenon of inducing the production of interleukin 18 (IL-18) by kerationcytes (KC) and methods of utilizing the same. IgE expression at a high level in the serum, which is observed in an AD-like lesion, can be reproduced by, for example, applying Staphylococcus aureus-origin protein A (SpA) on mouse skin or the like or transplanting a skin piece having an AD-like inflammatory lesion to a mouse or the like. Thus, it becomes possible to screen, for example, an inhibitor of the induction of IL-18 production by KC. |
申请公布号 |
WO2004104578(A1) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2004JP05747 |
申请日期 |
2004.04.21 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY;NAKANISHI, KENJI;MIZUTANI, HITOSHI;TSUTSUI, HIROKO |
发明人 |
NAKANISHI, KENJI;MIZUTANI, HITOSHI;TSUTSUI, HIROKO |
分类号 |
C07K14/54;G01N33/50;G01N33/68 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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