| 摘要 |
<p>The invention discloses a method for inactivating virus in circular blood, comprising the following steps:1) adding anti-coagulants to a whole blood source, and founding a whole blood source circulation system; 2) withdrawing the anticoagulable whole blood to a blood separating device, pumping red blood cell back to the whole blood source directly after separating, and transfusing plasma to a mixture transport pump; 3) adding photosensitizer like methylene blue to the mixture transport pump at the same time, and after mixing the methylene blue and the plasma, pumping the mixture to a plasma container; 4) inactivating the mixture in the plasma container with light source, and pumping the inactivated mixture to a photosensitizer remover; 5) absorbing the methylene blue with the photosensitizer remover, and returning the inactivated plasma to the whole blood source; 6) repeating step 2 to 5 until the virus load of the whole blood source depress 99.99%. The invention can deal with blood in batches, pipelining and circulation with a sterile and isolated oneoff closed system, and the inactivated plasma returning to the whole blood source can transfuse to organism directly. Further, the invention can be used in the treatment of Hepatitis-B virus, Hepatitis-A virus, AIDS virus and SARS virus etc, and the removement of the receptor virus in organ transplant.</p> |
