PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF
摘要
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.
申请公布号
WO2004062622(A3)
申请公布日期
2004.12.02
申请号
WO2004US00805
申请日期
2004.01.13
申请人
ATHEROGENICS, INC.;WEINGARTEN, M., DAVID;SIKORSKI, JAMES, A.