| 摘要 |
The present disclosure provides methods for preventing or treating illness, improving responsiveness to immunization, and improving the efficacy of gene therapy in patient by disrupting sex steroid signaling in the patient, where in the bone marrow and other immune cell functionality is improved without, pri or to, or currently with, thymic regeneration. In some embodiments, sex steroid signaling is interrupted or ablated in the patient by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selectiv e progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof. |
