发明名称 |
A-33 related antigens and their pharmacological uses |
摘要 |
A33 related antigens PRO301, PRO362 and PRO245, are new. Independent claims are also included for the following: (1) a nucleic acid comprising DNA having at least 95% sequence identity to: (a) a DNA molecule encoding PRO301 comprising amino acids 28-235 of a 299 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209432 (designated DNA40628-1216); or (c) the complement of DNA in (a); (2) a nucleic acid comprising DNA having at least 80% sequence identity to: (a) a DNA molecule encoding PRO362 comprising amino acids 1-321 or 1-X (X = any of residues 271-280) of a 321 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209620 (designated DNA45416-1251); or (c) the complement of DNA in (a); (3) production of PRO301, PRO362 or PRO245; isolated PRO301 comprising residues 28-235 of the 299 residue sequence; (4) isolated PRO362 comprising residues 1-229 or 1-X (X = 271-280) of the 321 residue sequence; (5) an isolated antibody which binds PRO301 or PRO362; (6) treating an inflammatory disease by administering a therapeutically effective amount of a PRO301, PRO362 or PRO245 antagonist or fragment; determining the presence of PRO301, PRO362 or PRO245; and (7) diagnosis of an inflammatory disease or tumor, by detecting the level of PRO301, PRO362 or PRO245 gene expression. ACTIVITY : Cytostatic; Anti-inflammatory. MECHANISM OF ACTION : Antagonist. |
申请公布号 |
EP1481989(A1) |
申请公布日期 |
2004.12.01 |
申请号 |
EP20040010432 |
申请日期 |
1998.11.20 |
申请人 |
GENENTECH, INC. |
发明人 |
ASHKENAZI, AVI;FONG, SHERMAN;GODDARD, AUDREY;GURNEY, AUSTIN L.;NAPIER, MARY A.;TUMAS, DANIEL;WOOD, WILLIAM I. |
分类号 |
C12N15/09;A61K;A61K31/711;A61K35/76;A61K38/00;A61K39/39;A61K39/395;A61K45/00;A61K48/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P5/14;A61P7/04;A61P7/06;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P21/00;A61P25/00;A61P25/02;A61P25/28;A61P29/00;A61P31/12;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P37/08;C07K;C07K14/47;C07K14/705;C07K16/18;C07K16/28;C07K16/42;C12N;C12N15/12;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;G01N33/53;G01N33/574;G01N33/577;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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