发明名称 |
Infectivity-enhanced conditionally-replicative adenovirus and uses thereof |
摘要 |
A modified adenovirus capable of overcoming the problem of low level of coxsackle-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to mutations in E1a or E1b genes.
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申请公布号 |
US6824771(B1) |
申请公布日期 |
2004.11.30 |
申请号 |
US20000569789 |
申请日期 |
2000.05.12 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
CURIEL DAVID T.;KRASNYKH VICTOR;ALEMANY RAMON;DMITRIEV IGOR |
分类号 |
A61K45/06;A61K48/00;C12N15/861;(IPC1-7):A61K35/76 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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