发明名称 Process for the preparation of cyclic lactic acid oligomers
摘要 The object of the present invention is to provide a novel method for effectively producing a cyclic lactic acid oligomer, and a cyclic lactic acid oligomer produced by the method. According to the present invention, there is provided a method for producing a cyclic lactic acid oligomer represented by the following formula (1):wherein m represents an integer of 1 to 30,wherein lactides are polymerized in the presence of an alkali metal compound represented by the following formula (2):wherein R represents an aliphatic group, aromatic group, -Si(R<10>)(R<11>)(R<12>), -CH(R<20>)CONR<21>R<22 >or -CH(R<30>)COOR<31>, wherein each of R<10>, R<11 >and R<12 >independently represents an aliphatic or aromatic group, R<20 >represents an aliphatic group, each of R<21 >and R<22 >independently represents a hydrogen atom, aliphatic group or aromatic group, R<30 >represents an aliphatic group, and R<31 >represents a hydrogen atom, aliphatic group or aromatic group;Y represents -O-, -S- or -NR<40>-, wherein R<40 >represents a hydrogen atom, aliphatic group or aromatic group; andMe represents an alkali metal; and,a cyclic lactic acid oligomer produced by the above production method.
申请公布号 US6825314(B1) 申请公布日期 2004.11.30
申请号 US20020070436 申请日期 2002.06.25
申请人 AMATO PHARMACEUTICAL PRODUCTS, LTD. 发明人 WATANABE MIKIO;TAKANO JIRO;ISHIHARA YOSHIMI;MURAKAMI MASAHIRO
分类号 C07D323/00;(IPC1-7):C08G63/00 主分类号 C07D323/00
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