| 摘要 |
The invention provides novel anilide compounds and pharmaceutical compositions comprising them.The invention relates to compounds of a formula:wherein Ar is an optionally-substituted aryl group;R4 and R5 are the same or different, and each is a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and R4 and R5 may together form a lower alkylene group of which one or more methylene moieties may optionally be substituted by oxygen and/or sulfur atoms;X is -NH-, or an oxygen or sulfur atom;Y is -NH-, an oxygen or sulfur atom, or a sulfoxide or sulfone group;Z is a single bond, or -NR6-;R4 represents a hydrogen atom or a lower alkylene group; andn is an integer of from 0 to 15;and their salts and solvates.The compounds of the invention are useful as pharmaceutical compositions, especially as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitors.
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