发明名称 |
NOVO METODO DE PREPARACAO DE DERIVADOS DE CICLOSPORINA |
摘要 |
The invention concerns a novel method for preparing a polyanion useful for preparing cyclosporin derivatives modified in position -3 by treating a cyclosporin with an alkali amide in liquid ammonia or in an aliphatic amine of low molecular weight, in the presence of a cosolvent, and optionally in the presence of dimethylpropyleneurea (DMPU). The treated cyclosporin has one or several free hydroxy groups and/or non-methylated nitrogen atoms in position alpha and/or any other acid group capable of being subjected to deprotonation and which are optionally subjected to deprotonation, or are in protected form. |
申请公布号 |
PT1040121(E) |
申请公布日期 |
2004.11.30 |
申请号 |
PT19980962475T |
申请日期 |
1998.12.16 |
申请人 |
AVENTIS PHARMA |
发明人 |
SERGE MIGNANI;JEAN-CLAUDE BARRIERE;GEORGES BASHIARDES;JEAN-CHRISTOPHE CARRY;MICHEL EVERS;BRUNO FILOCHE;GUY AMOURET;ANTONIO GUERREIRO;CHRISTIAN VISKOV |
分类号 |
C07K7/64;(IPC1-7):C07K7/64 |
主分类号 |
C07K7/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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