INHIBITION OF GENE EXPRESSION BY DELIVERY OF SPECIALLY SELECTED DOUBLE STRANDED OR OTHER FORMS OF SMALL INTERFERING RNA PRECURSORS ENABLING THE FORMATION AND FUNCTION OF SMALL INTERFERING RNA IN VIVO AND IN VITRO

摘要

The use of specially selected sequences from the target gene into designing double stranded or other forms of RNA (siRNA precursors or siRNAp) that enables small interfering RNA (siRNA) from this new invention is delivered for inhibition of cellular gene expression. Diseases may be prevented and treated by this process, e.g. Severe Acute Respiratory Syndrome (SARS) and Human Immunodeficiency Virus (HIV) infections. The process may be practiced in vivo or in vitro. The small interfering RNA enabled is of sequences usually of 23 nucleotides or less. The invented method of sequence selection from the target gene, however, may be applicable to double stranded RNA of any length.