Medicinal aerosol formulations

摘要

Use of particulate bulking agents having a small mass median diameter of less than one micron, preferably less than 300 nm, in the preparation of pharmaceutical aerosol formulations. The formulations comprise a suspension of drug particles in a propellant. Examples of bulking agents include ascorbic acid, saccharides, polysaccharides, amino acids, organic and inorganic salts, urea, and propyliodone. The process for the preparation of the aerosol formulation is also disclosed.