Novel compounds for use as HIV protease inhibitors

摘要

Disclosed are compounds of formula I, wherein: R1 is H, hydroxy or NHR2, R2 is H, alkyl, alkenyl, alkynyl, arylalkyl, heterocyclylalkyl, cycloalkyl, alkyl carbonyl, cycloalkyl carbonyl, aryl carbonyl, heterocyclyl carbonyl, aryl alkyl carbonyl, heterocyclyl alkyl carbonyl, alkyl oxy carbonyl, aryl, alkyl oxy carbonyl, heterocyclyl alkyl oxy carbonyl, aryl, heterocyclyl, sulfonyl, alkyl sulfonyl, aryl sulfonyl, heterocyclyl sulfonyl or a group of formula II, wherein X is O or S, or formula III, wherein Y is O or S, and the remaining substituents are defined herein. The compounds are used for the manufacture of medicaments for the treatment of HIV mediated diseases.