CRYSTALLINE ANHYDROUS AND MONOHYDRATE BENZOATE SALTS OF (2'S, 3S)-3 -HYDROXY -N-{2{N- METHYL-N -4-(N- PROPYLAMINO- CARBONYL) PHENYL] AMINO-2- PHENYL}- ETHYLPYRROLIDINE.

摘要

A process for preparing an anhydrous benzoate salt in crystallineform having formula (I) and the corresponding benzoate monohydrate in crystalline form. The benzoate salts and pharmaceutical compositions thereof are selective kappa-receptor agonists, and are useful as analgesics, anasthetics, anti-inflammatory or neuroprotective agents, or in the treatment of arthritis, stroke or functional bowel disease.