Antibodies specific for interleukin-1 alpha and interleukin-2 beta and methods of making and using

摘要

A dual-specificity antibody or antigen-binding portion thereof specifically binds interleukin-1alpha and interleukin-1beta wherein the antibody is not a fully mouse antibody. The antibody can be used in diagnostic methods for detecting IL-á or IL-â and in the manufacture of a medicament for treating interlauikin-1-related disorders such as inflammatory disorder, autoimmune disorder i.e. rheumatoid arthritis, Crohn's disease, multiple sclerosis, insulin dependant diabetes mellitus and psoriasis. Methods of obtaining dual-specificity antibodies and methods of making an antibody are also described.