Benzothiophene derivative compounds, process of preparation and use thereof as serotonin reuptake inhibitors with affinity to the 5-HT1A receptor to treat neurological disorders such as psychosis, depression, anxiety and panic attacks

摘要

The compound of formula (I) is defined wherein: n is 1, 2 or 3 Z is C=O or -CHOH R1 is H, alkyl C1-C6, halogen, -OR2, nitro, cyano, -NR3R4, -COR2, -CO2R2, -O-COR2, SO2NR3R4, -SO2R2, -SR2 or -CONR3R4 R2 is H, alkyl C1-C6 or phenyl; R3 and R4 are independent of each other and stand for H, alkyl C1-C6 or phenyl, or else R3 together with R4 form a morpholine, thiomorpholine or piperazine ring; Ar is an optionally substituted bicyclic system formed by a benzocondensed heterocyclic ring which has 5, 6 or 7 ring atoms, saturated or unsaturated and containing 1, 2 or 3 hetero-atoms selected from N, O and S. Also described is a process for preparing the compound of general formula (I). The compounds can be used in pharmaceutical compositions for use as serotonin reuptake inhibitors and antagonist or agonist of the 5-HT1A receptor and are useful in the treatment of neurological disorders such as depression, psychosis, anxiety, panic attacks, obsessive-compulsive disorders and nutrition disorders.