Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV, method ofr preparation, and their use

摘要

Dipeptidyl peptidase IV (DP 4) inhibiting compounds of formula (I) are disclosed, where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is CN; and wherein R1, R2, R3 and R4 are as described in the specification. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.