17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derviative as anti-inflammatory agents

摘要

Compounds of formula (I) are disclosed, wherein: R1 is alkyl or haloalkyl, R2 is -C(=O)-aryl or -C(=O)-heteroaryl, R3 is H, methyl or methylene, R4 and R5 are independently H or halogen, and the dotted line represents and optional double bond. The compounds are used in the manufacture of medicaments for the treatment of inflammatory and/or allergic conditions.