USE OF TRIGLYCERIDE OILS CONTAINING GAMMA-LINOLENIC ACID RESIDUES AND LINOLEIC ACID RESIDUES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE
摘要
<p>A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a triglyceride oil containing both gamma-linolenic acid and linoleic acid residues as triglyceride ester, the ratio of gamma-linolenic acid to linoleic acid residues at the sn-2 position of the triglyceride being at least 0.8; the amount of gamma -linolenic acid residues at the sn-2 position being at least 18 %, wherein the oil is administered at a dose sufficient to maintain or elevate TGF- beta1 levels in the patient at a therapeutic level. Preferably the method is that wherein the therapeutic level is such as to produce a TGF- betal/TNF-alpha ratio of at least 0.5 in blood of a patient, after 18 months of daily dosing. Preferre oils are Borage or Mucor oils having at least 35 % of the sn-2 position fatty acid residues as gamma-linolenic acid.</p>
申请公布号
WO2004100943(A1)
申请公布日期
2004.11.25
申请号
WO2004GB02089
申请日期
2004.05.14
申请人
BTG INTERNATIONAL LIMITED;HARBIGE, LAURENCE, S.;LEACH, MICHAEL, J.;SHARIEF, MOHAMMED
发明人
HARBIGE, LAURENCE, S.;LEACH, MICHAEL, J.;SHARIEF, MOHAMMED