USE OF QUINAZOLINE DERIVATIVES OR OTHER COMPOUNDS FOR INHIBITING DIHYDROFOLATE REDUXTASE; SCREENING ASSAY FOR THE IDENTIFICATION OF NOVEL THERAPEUTICS AND THEIR CELLULAR TARGETS

摘要

A novel screening assay for identifying therapeutic agents and their cellular targets is described. The assay is useful in developing new antibacterial, antifungal, antiparasitic and anti cancer therapeutics. New inhibitors of dihydrofolate reductase (DHFR) have been identified using the assay of the present invention. Methods of treating diseases that benefit from an inhibition of DHFR are also described.