CYCLIZED PEPTIDES AS EXOTOXIN ANTAGONISTS

摘要

tThe invention relates to peptides comprising eight to twelve amino acids, cyclized by backbone-to-backbone or backbone-to-side chain bridge, and is further directed to the use of the peptides for treating and preventing severe effects of bacterial pyrogenic exotoxins, including incapacitation induced by exposure to the exotoxins. The peptides antagonize exotoxin-mediated activation of T-lymphocytes, and elicit protective immunity against toxic shock induced by one or more pyrogenic exotoxins.