THERMOLABILE HYDROXYL PROTECTING GROUPS AND METHODS OF USE

摘要

Provided is a hydroxyl-protected alcohol comprising a thermolabile hydroxyl-protecting group comprising a 2-pyridyl substituent and a precursor of the thermolabile hydroxyl-protected alcohol. An exemplary thermolabile hydroxyl-protected alcohol is represented by the formula Pg-O-R, wherein Pg is a protecting group of the formula : (Formula) wherein : A is a 2-pyridyl; Z is CH2 or NR<1>; R<1>, R<2>, R<2'>, R<3> and R<3'> are the same or different and each can be, e.g., H, alkyl, or alkyl comprising an aryl substituent; W is CO, CS, or SO; and R is the organic residue of the hydroxyl-protected alcohol. Also provided is a method of producing an alcohol, which method comprises heating the hydroxyl-protected alcohol, which optionally may be obtained from a precursor, at a temperature effective to cleave the hydroxyl-protecting group. The method can be used to produce oligonucleotides.