SYNTHESIS OF SUBSTITUTED HETEROCYCLIC COMPOUNDS

摘要

The invention relates to a method of synthesising heterocyclic compounds. The invention is characterised in that it consists in opening a compound having formula (I), wherein: - X represents NH, O, S or a N-p group, p being a protective group, such as Boc or Troc; - Y represents N, O, S; - Z represents NH2 or NH-p; and - R1 represents a C1-C6 alkoxy radical, aryloxy, such as phenyloxy, or a pyrrolyl radical, said radicals being optionally substituted, or the salts thereof, and the isomers of the aforementioned compounds. Moreover, the above-mentioned opening step is performed in conditions such as to produce a heterocycle having formula (II), wherein: - X, Y and Z are as defined above; - R2 represents a -CH=CH-CH2-NH-COR1 or -CH=CH-CH2-NH-CO group; and R3 occupies one, two or three positions and represents a halogen. The invention can be used to synthesise natural products.