NOVEL USES OF PPAR MODULATORS AND PROFESSIONAL APCS MANIPULATED BY THE SAME

摘要

PPAR modulator treatment in monocyte derived APC cells the expression pattern of certain cell surface molecules, e.g. of CD 1 gene family, and the cytokine secretion pattern altered. The invention relates to a manipulated professional antigen presenting cell (APC) having increased expression of a CD1 type II molecule, preferably at least a CDld molecule, relative to a control non manipulated cell. The invention further relates to the use of PPARg modulators in the preparation of a pharmaceutical composition or kit for the treatment of a disease treatable by activation of CDld restricted T-cells, e.g. in autoimmune diseases, allergies, post-transplant conditions or infectious diseases, or in the treatment of a neoplastic disease, e.g. skin cancer, hematological tumors, colorectal carcinoma, and therapeutic compositions and kits therefor. Furthermore, the invention relates to methods of manipulating professional apcs and kits therefor.