METHODS FOR PREVENTING AND TREATING CANCER USING N-THIOLATED beta-LACTAM COMPOUNDS AND ANALOGS THEREOF

摘要

The subject invention concerns N-thiolated beta-lactam compounds, their analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated beta-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.