HUMAN P53 SPLICE VARIANT DISPLAYING DIFFERENTIAL TRANSCRIPTIONAL ACTIVITY

摘要

Described is a nucleic acid molecule encoding a p53 variant characterized in that it is capable of transactivating the p21- and 14-3-3sigma -promoter but not the mdm2-, bax- and PIG3 -promoter. Preferably, in said p53 variant exon 7, exon 8 and/or exon 9 are partially or entirely deleted. Finally, means for inhibiting the activity of this p53 variant are described which are useful for the therapy of cancer.