TREATMENT OF METABOLIC DISORDERS

摘要

The present invention relates to methods for the treatment of metabolic disorders, including diabetes mellitus type 2, associated with mutations/polymorphisms in the promoter region of muscle glycogen synthase. The invention comprises the use of compounds to raise the level of activity of muscle glycogen synthase, either by increasing gene expression or by directly or indirectly increasing the enzyme activity. Furthermore, the invention relates to gene therapy methods and to constructs for use in these. The invention also relates to methods, vectors and host cells for screening for compounds for activity against metabolic disorders of the type described.