APOPTOLIDIN ANALOGS AND DERIVATIVES FOR INDUCING APOPTOSIS IN TRANSFORMED CELLS
摘要
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivatives and stereoisomers thereof; and deglycosylated isoapoptolidin and selectively functionalized derivatives and stereoisomers thereof. The isoapoptolidin, apoptolidin, and deglycosylated isoapoptolidin derivatives may be functionalized by substituting any or all of the methoxyl or hydroxyl groups of the parent molecule. Pharmaceutical compositions and methods for using the compounds are also provided.
申请公布号
WO2004062629(A3)
申请公布日期
2004.11.25
申请号
WO2004US00935
申请日期
2004.01.13
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;WENDER, PAUL, A.;JANKOWSKI, ORION, D.;TABET, ELIE, A.
发明人
WENDER, PAUL, A.;JANKOWSKI, ORION, D.;TABET, ELIE, A.