发明名称 |
PROTEIN S PROTECTS THE NERVOUS SYSTEM FROM INJURY |
摘要 |
Protein S is a significant neuroprotectant when administered after focal ischemic stroke and prevents hypoxic/re-oxygenation injury. Purified human plasma-derived or recombinant protein S improves motor neurological function after stroke, and reduced brain infarction and edema. Protein S also enhances post-ischemic reperfusion and reduced brain fibrin and neutrophil deposition. Cortical neurons are protected from hypoxia/re-oxygenation-induced apoptosis. Thus, protein S and variants thereof are prototypes of a class of agents for preventing injury of the nervous system. In particular, a disease or other pathological condition (e.g., stroke) may be treated with such agents having one or more protein S activities (e.g., anti-thrombotic and anti-inflammatory activities, direct cellular neuronal protective effects) although the latter activities are not be required.
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申请公布号 |
WO2004030619(A8) |
申请公布日期 |
2004.11.25 |
申请号 |
WO2003US30638 |
申请日期 |
2003.09.30 |
申请人 |
SOCRATECH L.L.C.;THE UNIVERSITY OF ROCHESTER;THE SCRIPPS RESEARCH INSTITUTE;ZLOKOVIC, BERISLAV, V.;GRIFFIN, JOHN, H. |
发明人 |
ZLOKOVIC, BERISLAV, V.;GRIFFIN, JOHN, H. |
分类号 |
A61K38/36;C07K14/81;(IPC1-7):A61K/ |
主分类号 |
A61K38/36 |
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