| 发明名称 |
Expression system |
| 摘要 |
A recombinant microorganism comprises an asporogenic Bacillus subtilis strain in which a gene encoding a protease enzyme has been downregulated or inactivated. In particular sigma factorspoIIAC is inactivated such that the strain is asporogenic. These strains are particularly useful as expression vehicles for proteins such as protective antigen (PA) of Bacillus anthracis.
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| 申请公布号 |
US2004235140(A1) |
申请公布日期 |
2004.11.25 |
| 申请号 |
US20040483150 |
申请日期 |
2004.06.25 |
| 申请人 |
WILLIAMSON ETHEL DIANE;BAILLIE LESLIE WILLIAM JAMES;MILLER JULIE |
发明人 |
WILLIAMSON ETHEL DIANE;BAILLIE LESLIE WILLIAM JAMES;MILLER JULIE |
| 分类号 |
C12N15/09;C07K14/32;C12N1/21;C12N15/75;C12P21/02;C12R1/125;(IPC1-7):A61K39/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
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