发明名称 |
Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
摘要 |
The present invention relates to the use of a compound or a plurality of compounds that inhibit function of Hsp90; or activate expression of both Hsp40 and Hsp70 for the preparation of a pharmaceutical composition for the prevention or treatment of a disease associated with protein aggregation and amyloid formation. Preferably, said compound is geldanamycin. The present invention relates further to methods of producing compounds within proved potency and/or decreased side-effects that may be successfully employed as medicaments for the treatment of said diseases.
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申请公布号 |
US2004235813(A1) |
申请公布日期 |
2004.11.25 |
申请号 |
US20040476812 |
申请日期 |
2004.05.10 |
申请人 |
WANKER ERICH;SITTLER ANNIE;HARTL ULRICH |
发明人 |
WANKER ERICH;SITTLER ANNIE;HARTL ULRICH |
分类号 |
A61K31/00;A61K31/365;A61K31/395;A61P25/28;G01N33/68;(IPC1-7):A61K31/33 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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