SERUM PROTEIN PROFILING FOR THE DIAGNOSIS OF EPITHELIAL CANCERS

摘要

The present invention provides biomolecules and the use of these biomolecule s for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a databas e comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.