发明名称 |
Production of multimeric proteins |
摘要 |
The present invention provides a new, effective and efficient method of producing multimeric proteins in an individual. Multimeric proteins include associated multimeric proteins (two or more associated polypeptides) and multivalent multimeric proteins (a single polypeptide encoded by more than one gene of interest). Expression and/or formation of the multimeric protein in the individual is achieved by administering a polynucleotide cassette containing genes of interest that encode portions of the multimeric protein to the individual. The polynucleotide cassette may additionally contain one or more pro sequences, prepro sequences, cecropin prepro sequences, and/or cleavage site sequences.
|
申请公布号 |
US2004235011(A1) |
申请公布日期 |
2004.11.25 |
申请号 |
US20030746943 |
申请日期 |
2003.12.24 |
申请人 |
COOPER RICHARD K.;FIORETTI WILLIAM C.;CADD GARY G. |
发明人 |
COOPER RICHARD K.;FIORETTI WILLIAM C.;CADD GARY G. |
分类号 |
A01K67/027;A61K39/00;A61K48/00;C07K14/62;C07K16/00;C07K16/02;C07K16/10;C07K16/26;C12N15/85;(IPC1-7):C12Q1/68;A01K67/00;C07H21/04;C12P21/04 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|