发明名称 |
Means for eliciting an immune response and a method therefor |
摘要 |
A means to elicit a cytotoxic immune response as a result of injecting antigen encoding expression constructs. Minimalistic expression constructs are used that comprise a promoter, a coding sequence and a terminator, and hairpin-shaped oligonucleotides on their ends, to the loop of which cationic peptides are covalently attached. These peptide-coupled expression constructs lead to a cell mediated response type after intradermal injection. The use of a DNA expression construct operable in eucaryotic cells for making a vaccine for intradermal injection to elicit a type 1 cell mediated immune mediated immune response is described.
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申请公布号 |
US2004235771(A1) |
申请公布日期 |
2004.11.25 |
申请号 |
US20040816465 |
申请日期 |
2004.04.01 |
申请人 |
MORENO-LOPEZ SONIA;TIMON-JIMENEZ MARCOS |
发明人 |
MORENO-LOPEZ SONIA;TIMON-JIMENEZ MARCOS |
分类号 |
C07K14/02;C12N15/51;C12N15/85;C12N15/87;(IPC1-7):A61K48/00 |
主分类号 |
C07K14/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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