Kinetic isolation pressurization

摘要

A method of delivering a therapeutic agent to a targeted location within a patient efficiently delivers the agent with a reduced systemic effect. The method includes providing a non-perforated delivery device having at least one wall through which a fluid at first fluid pressure can pass through. The non-perforated delivery device is positioned to provide a radial fluid force against the targeted location. The fluid, including at least one therapeutic agent, is supplied to the therapeutic agent delivery device at the first fluid pressure. The fluid passes through the at least one wall of the delivery device to create a semi-confined space external to the delivery device at a second fluid pressure. The delivery device applies the radial fluid force against the semi-confined space and the fluid disposed therein while simultaneously facilitating the fluid passing through the delivery device to maintain the second fluid pressure in the semi-confined space at the targeted location. The fluid contains at least one therapeutic agent that is distributed to the targeted location in a substantially uniform distribution in an amount sufficient to create a therapeutic effect modulatable by the fluid pressure and a dwell time.