INFECTIOUS BRONCHITIS VIRUS WITH AN ALTERED SPIKE GENE
摘要
The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.
申请公布号
WO2004078203(A3)
申请公布日期
2004.11.25
申请号
WO2004EP50247
申请日期
2004.03.03
申请人
AKZO NOBEL N.V.;INSTITUTE FOR ANIMAL HEALTH;CAVANAGH, DAVID;BRITTON, PAUL;TARPEY, IAN