摘要 |
The invention refers to a novel process for the preparation of {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group. |
申请人 |
EGIS GYOGYSZERGYAR RT., BUDAPEST |
发明人 |
REITER, JETAZSEF;TRINKA, PETER;BARTHA, FERENC;SIMIG, GYULA;NAGY, KALMAN;VERECZKEYNE DONATH, GYOERGYI;NEMETH, NORBERT;, H-9400 SOPRON;CLEMENTIS, GYOERGY;, H-1118 BUDAPEST;TOEMPE, PETER;VAGO, PAL |