PROCESS FOR THE PREPARATION OF 7-ALKYL-10-HYDROXY-20(S)-CAMPTOTHECIN

摘要

The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy- 20(S) camptothecin. A process for the efficient synthesis of this intermedia te is demonstrated proceeding through readily availabe 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10 - hydroxy-20(S)-camptothecin intermediates.