发明名称 |
Polymorfi i det humane MDR-1-gen og anvendelser deraf |
摘要 |
Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the Multi Drug Resistance-1 (MDR-1) gene. In particular, polynucleotides of molecular variant MDR-1 genes which, for example, are associated with unsufficient and/or altered uptake of drugs by a target cell, and vectors comprising such polynucleotides are provided. Furthermore, host cells comprising such polynucleotides or vectors and their use for the production of variant MDR-1 proteins are described. In addition, variant MDR-1 proteins and antibodies specifically recognizing such proteins as well as concerns transgenic non-human animals comprising the above-described polynucleotide or vectors are provided. Described are also methods for identifying and obtaining inhibitors for therapy of disorders related to the malfunction of the MDR-1 gene as well as methods of diagnosing the status of such disorders. Pharmaceutical and diagnostic compositions comprising the above-described polynucleotides, vectors, proteins, antibodies and inhibitors by the above-described method are provided. Said compositions are particularly useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of the MDR-1 gene product. |
申请公布号 |
DK1232260(T3) |
申请公布日期 |
2008.02.04 |
申请号 |
DK20000972654T |
申请日期 |
2000.07.28 |
申请人 |
EPIDAUROS BIOTECHNOLOGIE AG |
发明人 |
BRINKMANN, ULRICH;HOFFMEYER, SVEN;EICHELBAUM, MICHEL;ROOTS, IVAR |
分类号 |
A01K67/027;C12N15/12;A61K31/436;A61K31/7088;A61K31/711;A61K38/00;A61K45/00;A61K48/00;A61P9/04;A61P25/08;A61P31/04;A61P35/00;A61P37/06;A61P43/00;C07K14/47;C07K14/705;C07K16/18;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12N15/11;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|