发明名称 |
DIAGNOSTIC AND THERAPEUTIC USE OF MA ONCONEURONAL ANTIGENS FOR NEURODEGENERATIVE DISEASES |
摘要 |
The present invention discloses the differential expression of the onconeuronal antigen Ma2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for an onconeuronal antigen, in particular Ma2 onconeuronal antigen. A method of screening for modulating agents of neurodegenerative diseases is also disclosed. |
申请公布号 |
EP1478930(A2) |
申请公布日期 |
2004.11.24 |
申请号 |
EP20030709723 |
申请日期 |
2003.02.26 |
申请人 |
EVOTEC NEUROSCIENCES GMBH |
发明人 |
HIPFEL, RAINER;VON DER KAMMER, HEINZ;POHLNER, JOHANNES |
分类号 |
A61K38/00;C07K16/32;C12Q1/68;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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