发明名称 |
Oral pharmaceutical compositions containing taxanes and methods for treatment employing the same |
摘要 |
Pharmaceutical compositions for oral administration to mammalian subjects comprise a taxane or taxane derivative (e.g. paclitaxel or docetaxel) as active ingredient and a vehicle comprising at least 30% by weight of a carrier for the taxane, said carrier having an HLB value of at least about 10. The compositions may also comprise 0 - 70% of a viscosity-reducing co-solubilizer. The compositions may be incorporated into conventional oral pharmaceutical dosage forms, or can be in the form of a two-part medicament wherein the first part includes the taxane in a solubilizing vehicle and the second part comprises a carrier for the taxane to promote oral absorption. Methods of treatment of taxane-responsive disease conditions employing the novel compositions are also disclosed, whereby the compositions can be administered alone or in association with an oral bioavailability enhancing agent.
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申请公布号 |
EP1479382(A1) |
申请公布日期 |
2004.11.24 |
申请号 |
EP20040077062 |
申请日期 |
1999.06.18 |
申请人 |
IVAX RESEARCH, INC. |
发明人 |
CACASE, JANICE L.;RUTLEDGE, J. MICHAEL;TESTMAN, ROBERT;GUTIERREZ-ROCCA, JOSE;SELIM, SAMI |
分类号 |
A61K9/48;A61K31/337;(IPC1-7):A61K9/48 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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