| 摘要 |
The present invention includes Fcepsilon fragments conjugated with FCgamma fragments, for example, Fcepsilon1-Hinge-FcE2-FcE3-FcE4-FCy; Hinge-FcE2-FcE3-FcE4-Fcy; FCepsilon2-Fcepsilon3-Fcepsilon4-FCgamma; FCepsilon2-Fcepsilon3-Fcgamma; FCepsilon3-Fcgamma; and FCepsilon3-Fcepsilon4-FCgamma, or any derivative or peptide, which has equivalent immunological function. The Fcgamma fragment may be a fragment of any of the IgG subclasses (IgG1 I IgG2, IgG3, or IgG4), preferably IgG1 or IgG3, wherein the fragment binds FcgammaRIIB. The present invention also includes compositions suitable for administering to a patient suffering from an allergic disease comprising the fusion protein construct in a pharmaceutical composition including, for example, an excipient, diluant, or carrier. This treatment may be combined with anti-IgE therapy or allergen immunotherapy. |
